P. Jeffrey Conn,Craig W. Lindsley,Shaun R. Stauffer,José Manuel Bartolomé-Nebreda,Susana Conde-Ceide,Gregor James Macdonald,Han Min Tong,Miguel Angel Pena-Piñón,Manuel Jesús Alcázar-Vaca,José Ignacio
申请号:
US13922223
公开号:
US09029366B2
申请日:
2013.06.19
申请国别(地区):
US
年份:
2015
代理人:
摘要:
In one aspect, the invention relates to substituted bicyclic alkoxy pyrazole analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.