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INHIBITORS OF 1 KINASE OF THE CELL CYCLE CONTROL POINT FOR STRENGTHENING DNA-DAMAGING AGENTS
专利权人:
ЭРРЭЙ БИОФАРМА ИНК. (US)
发明人:
ХАМФРИС Майкл Дж. (US),ВИНСКИ Шаннон Л. (US)
申请号:
RU2011145773/15
公开号:
RU2011145773A
申请日:
2010.04.09
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. '926 CHK1 inhibitor for administration to a patient with cancer to enhance the DNA damaging agent, wherein the administration of the CHK1 inhibitor follows the administration of the DNA damaging agent and is carried out in two doses, the first of which is administered one day after the DNA damaging agent, and the second, two days after the DNA damaging agent. 2. The SNK1 inhibitor according to claim 1 for administration to a patient with cancer to enhance the DNA damaging agent, wherein the introduction of the SNK1 inhibitor follows the introduction of the DNA damaging agent and is carried out in three doses, the first of which is administered one day after the DNA damaging agent, the second dose - two days after the DNA damaging agent, and the third dose - three days after the DNA damaging agent. 3. The CHK1 inhibitor according to claim 1, characterized in that the '926 CHK1 inhibitor is (R) -N- (4- (3-aminopiperidin-1-yl) -5-bromo-1H-pyrrole [2,3-b] pyridin-3-yl) nicotinamide 1.4. The CHK1 inhibitor according to claim 1, characterized in that the '926 CHK1 inhibitor is (R) -N- (4- (3-aminopiperidin-1-yl) -5-bromo-1H-pyrrole [2,3-b] pyridin-3-yl) isobutyramide. 5. The CHK1 inhibitor according to claim 1, characterized in that the '926 CHK1 inhibitor is (R) -N- (5-bromo-4- (3- (methylamino) piperidin-1-yl) -1H-pyrrole [2,3 -b] pyridin-3-yl) nicotinamide. 6. The CHK1 inhibitor according to claim 1, characterized in that the '926 CHK1 inhibitor is (R) -N- (4- (3-aminopiperidin-1-yl) -5-bromo-1H-pyrrole [2,3-b] pyridin-3-yl) -5-methylnicotinamide. 7. The CHK1 inhibitor according to claim 1, characterized in that the '926 CHK1 inhibitor is (R) -N- (4- (3-aminopiperidin-1-yl) -5-bromo-1H-pyrrole [2,3-b] pyridin-3-yl) piclopropanecarboxamide. 8. The CHK1 inhibitor according to claim 1, characterized in that the '926 CHK1 inhibitor is (R) -N- (4- (3-aminopiperidin-1-yl) -5-1. '926 ингибитор СНК1 для введения пациенту с раковым заболеванием для усиления ДНК-повреждающего
来源网站:
中国工程科技知识中心
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