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Inhibitors of control point kinase 1 for potentiation of DNA damaging agents
专利权人:
Array Biopharma; Inc.
发明人:
HUMPHRIES, Michael J.,WINSKI, Shannon L.
申请号:
ES10721579
公开号:
ES2608656T3
申请日:
2010.04.09
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A checkpoint kinase 1 inhibitor (CHK1) selected from the group consisting of (R) -N- (4- (3- aminopiperidin-1-yl) -5-bromo-1H-pyrrolo [2,3-b] pyridin-3-yl) nicotinamide; (R) -N- (4- (3-aminopiperidin-1-yl) -5-bromo-1Hpyrrolo [2,3-b] pyridin-3-yl) isobutyramide; (R) -N- (5-bromo-4- (3- (methylamino) piperidin-1-yl) -1H-pyrrolo [2,3-b] pyridin-3- yl) nicotinamide; (R) -N- (4- (3-aminopiperidin-1-yl) -5-bromo-1H-pyrrolo [2,3-b] pyridin-3-yl) -5-methylnicotinamide; (R) -N- (4- (3- aminopiperidin-1-yl) -5-bromo-1H-pyrrolo [2,3-b] pyridin-3-yl) cyclopropanecarboxamide, (R) -N- (4- (3-aminopiperidin-1-yl) -5-bromo-1H-pyrrolo [2,3-b] pyridin-3-yl) -3-methylbutanamide; and (R) -N- (4- (3-aminopiperidin-1-yl) -5-bromo-1H-pyrrolo [2,3- b] pyridin-3-yl) -2-cyclopropylacetamide for administration to a patient suffering from cancer for use in potentiating a DNA damaging agent in a method of treating cancer, wherein the administration of the CHK1 inhibitor follows the administration of the DNA damaging agent, wherein the CHK1 inhibitor is administered in two doses, the first dose of CHK1 inhibitor is administered one day after the DNA damaging agent and the second dose of CHK1 inhibitor is administered two days after the DNA damaging agent.Un inhibidor de quinasa de punto de control 1 (CHK1) seleccionado del grupo constituido por (R)-N-(4-(3- aminopiperidin-1-il)-5-bromo-1H-pirrolo[2,3-b]piridin-3-il)nicotinamida; (R)-N-(4-(3-aminopiperidin-1-il)-5-bromo-1Hpirrolo[ 2,3-b]piridin-3-il)isobutiramida; (R)-N-(5-bromo-4-(3-(metilamino)piperidin-1-il)-1H-pirrolo[2,3-b]piridin-3- il)nicotinamida; (R)-N-(4-(3-aminopiperidin-1-il)-5-bromo-1H-pirrolo[2,3-b]piridin-3-il)-5-metilnicotinamida; (R)-N-(4-(3- aminopiperidin-1-il)-5-bromo-1H-pirrolo[2,3-b]piridin-3-il)ciclopropanocarboxamida, (R)-N-(4-(3-aminopiperidin-1-il)-5- bromo-1H-pirrolo[2,3-b]piridin-3-il)-3-metilbutanamida; y (R)-N-(4-(3-aminopiperidin-1-il)-5-bromo-1H-pirrolo[2,3- b]piridin-3-il)-2-ciclopropilacetamida para la administra
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