Described herein are compounds that are inhibitors of autotaxin. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such inhibitors, alone and in combination with other compounds, for treating autotaxin-dependent or autotaxin-mediated conditions or diseases.本文闡述為自分泌運動因子(autotaxin)之抑制劑的化合物。本文亦闡述包括本文所述化合物之醫藥組合物及藥劑、以及該等抑制劑單獨及與其他化合物組合使用來治療自分泌運動因子依賴性或自分泌運動因子介導之病況或疾病之方法。