Compounds of Formula 1 as inhibitors of protein tyrosine phosphatase SHP2 are disclosed. The pharmaceutical compositions comprising compounds of Formula 1, methods of synthesis of these compounds, methods of treatment for diseases associated with the aberrant activity of SHP2 such as cancer using these compounds or compositions containing these compounds are also disclosed.本發明提供一種可作為蛋白酪胺酸磷酸酶SHP2之抑製劑的式1化合物，以及包含式1化合物的醫藥組合物。本發明亦提供一種製備本發明化合物的方法，以及使用本發明化合物或含有該些化合物的組合物來治療SHP2活性異常之相關疾病(例如，癌症)的方法。
