Indiana University Research and Technology Corporation
发明人:
Zhong-Yin Zhang,Rongjun He
申请号：
US15577417
公开号：
US20180170862A1
申请日:
2016.06.01
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Small molecule compounds derived from α-sulfophenylacetic amide (SPAA) are provided as novel sulfonic acid based pTyr mimetics. These compounds effectively inhibit a variety of protein tyrosine phosphatases (PTPs), such as mPTPA, mPTPB, LMWPTP, and Laforin. Use of these compounds as pharmaceutical agents for treating diseases associated with abnormal protein tyrosine phosphatase activity is also provided.
