The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in the treatment of an ATX-dependent or ATX-mediated disease or condition.本發明係關於為自分泌運動因子(autotaxin)抑制劑之新穎化合物、其製備方法、含有其之醫藥組合物及醫藥以及其在治療ATX依賴性或ATX介導之疾病或病況中之用途。