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FORMULATIONS SOLIDES D'AGENTS LIQUIDES BIOLOGIQUEMENT ACTIFS
专利权人:
LABOPHARM EUROPE LIMITED;LABOPHARM (BARBADOS) LIMITED;LABOPHARM INC.
发明人:
RAVENELLE, FRANCOIS,GORI, SANDRA,LESSARD, DAVID,LUO, LAIBIN,LE GARREC, DOROTHEE,SMITH, DAMON
申请号:
EP05815074
公开号:
EP1817035A4
申请日:
2005.11.28
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
The instant invention relates to a solid product comprising a liquid biologically active agent which is intimately associated to a stabilizing agent; particularly a solid product that can be reconstituted to a clear, stable, stabilized nanodispersion or loaded micelles comprising a polymer as a stabilizing agent and a liquid, preferably water immiscible, biologically active agent. The instant invention is further directed toward a process for the production of the above solid product; particularly to micelles or nanodispersions produced by hydration of a cake or powder of the solid product, produced via an effective treatment of a stabilized solution comprising for example a polymer as a stabilizing agent, such as an amphiphilic block copolymer or a small molecular weight surfactant, loaded with a liquid biologically active agent, such as propofol, an optional additive, and a suitable solvent.
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