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Solid formulation of liquid biologically active substance
专利权人:
パラディン ラブス インコーポレーテッド
发明人:
ラヴァネル フランソワ,ゴリー サンドラ,ルサール ディヴィッド,ルオ レバン,ル ガル ドロテー,スミス デイモン
申请号:
JP2007541612
公开号:
JP5704787B2
申请日:
2005.11.28
申请国别(地区):
JP
年份:
2015
代理人:
摘要:
The instant invention relates to a solid product comprising a liquid biologically active agent which is intimately associated to a stabilizing agent; particularly a solid product that can be reconstituted to a clear, stable, stabilized nanodispersion or loaded micelles comprising a polymer as a stabilizing agent and a liquid, preferably water immiscible, biologically active agent. The instant invention is further directed toward a process for the production of the above solid product; particularly to micelles or nanodispersions produced by hydration of a cake or powder of the solid product, produced via an effective treatment of a stabilized solution comprising for example a polymer as a stabilizing agent, such as an amphiphilic block copolymer or a small molecular weight surfactant, loaded with a liquid biologically active agent, such as propofol, an optional additive, and a suitable solvent.
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