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COMPLEXE DE TOMOXIPROLE AMORPHE ET DE CYCLODEXTRINE PRESENTANT UNE VITESSE DE DISSOLUTION ELEVEE ET SON PROCEDE DE PREPARATION
专利权人:
FONDAZIONE ISTITUTO INSUBRICO DI RICERCA PER LA VITA;FONDAZIONE CARIPLO
发明人:
MILANESE, ALBERTO,NEBULONI, MARINO,CARRANO, LUCIA
申请号:
CA2835232
公开号:
CA2835232A1
申请日:
2012.06.14
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
A stable complex of tomoxiprole with 2-hydroxypropyl-beta-cyclodextrin with fast dissolution rate and rapid absorption wherein amorphous tomoxiprole forms a complex with 2-hydroxypropyl-beta-cyclodextrin in about equimolecular ratio. The complex shows a remarkably faster dissolution rate and absorption with respect to crystalline tomoxiprole and is particularly suitable for the production of pharmaceutical oral dosage forms, such as tablets and capsules, where rapid onset of therapeutical action is required. A method of manufacture of the complex is also described and claimed.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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