FONDAZIONE ISTITUTO INSUBRICO DI RICERCA PER LA VITA;FONDAZIONE CARIPLO
发明人:
MILANESE, ALBERTO,NEBULONI, MARINO,CARRANO, LUCIA
申请号:
CA2835232
公开号:
CA2835232A1
申请日:
2012.06.14
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
A stable complex of tomoxiprole with 2-hydroxypropyl-beta-cyclodextrin with fast dissolution rate and rapid absorption wherein amorphous tomoxiprole forms a complex with 2-hydroxypropyl-beta-cyclodextrin in about equimolecular ratio. The complex shows a remarkably faster dissolution rate and absorption with respect to crystalline tomoxiprole and is particularly suitable for the production of pharmaceutical oral dosage forms, such as tablets and capsules, where rapid onset of therapeutical action is required. A method of manufacture of the complex is also described and claimed.