MURPHY ANDREW J.,SLEEMAN MARK W.,GUSAROVA VIKTORIA
申请号：
NZ61909212
公开号：
NZ619092A
申请日:
2012.06.14
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed is an isolated human antibody or antigen-binding fragment thereof that specifically binds human angiopoietin-like protein 3 (hANGPTL3) of SEQ ID NO:161 and neutralizes, reduces, or interferes with, at least one activity of hANGPTL3, and wherein the antibody binds amino acids 36-68 of AngPTL3, and wherein the antibody or antigen-binding fragment comprises a heavy chain variable region (HCVR) selected from the group consisting of SEQ ID NO:2, 18, 34, 50, 66, 82, 98, 114, 130, 146 and 180 and a light chain variable region (LCVR) selected from the group consisting of SEQ ID NO:10, 26, 42, 58, 74, 90, 106, 122, 138, 154 and 188.
