NZ 600348 Disclosed is a binding moiety which binds to a conformational epitope formed by amino acid sequences NDETCEQRA (SEQ ID NO: 2) and SHKDMQL (SEQ ID NO: 3) of C5a, wherein the binding moiety binds to at least one amino acid within the amino acid sequence according to SEQ ID NO: 2 and to at least one amino acid within the amino acid sequence according to SEQ ID NO: 3 wherein said binding moiety has a binding constant to C5a with a Kd value of 100 nM or less wherein said binding moiety is selected from the group consisting of: (a) antibodies or antigen-binding fragments thereof and (b) antibody-like proteins.
