ACTIVE PROTEASE RESISTANT ANTIBODY FC MUTANTS

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专利权人:

发明人:

STROHL WILLIAM,JORDAN ROBERT,BREZSKI RANDALL

申请号：

IN5526/DELNP/2013

公开号：

IN2013DN05526A

申请日:

2013.06.20

申请国别(地区):

IN

年份:

2014

代理人:

摘要：

Monoclonal antibody and other Fc containing molecules can be constructed using the disclosed variations in the Fc region causing increased resistance to host and pathogen derived proteases and exhibiting the ability to interact with Fey receptors and initiate complement directed cytotoxicity as demonstrated by functional assays. The Fc containing molecules are useful in the treatment of various diseases and disorders wherein FcR driven host functions contribute activity.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/