KUTRYK, MICHAEL JOHN BRADLEY,COTTONE, ROBERT J., JR.,ROWLAND, STEPHEN M.
申请号：
CA2563329
公开号：
CA2563329C
申请日:
2005.04.29
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Therapeutic and drug delivery systems are provided in the form of medicaldevices with coatings for capturing and immobilizing target cells such ascirculating progenitor or genetically-altered mammalian cells in vivo. Thegenetically-altered cells are transfected with genetic material for expressinga marker gene and at least one therapeutic gene in a constitutively orcontrolled manner. The marker gene is a cell membrane antigen not found incirculating cells in the blood stream and therapeutic gene encodes a peptidefor the treatment of disease, such as, vascular disease and cancer. Thecoating on the medical device may be a biocompatible matrix comprising atleast one type of ligand, such as antibodies, antibody fragments, otherpeptides and small molecules, which recognize and bind the target cells. Thetherapeutic and/or drug delivery systems may be provided with a signal sourcesuch as activator molecules for stimulating the modified cells to express andsecrete the desired marker and therapeutic gene products.
