Systemic virus / ligand gene delivery system and gene therapy

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专利权人:

ジョージタウン・ユニバーシティ;ジョージタウン・ユニバーシティ;シナージーン・セラピューティックス・インコーポレイテッド

发明人:

エスター・エイチ・チャン,キャスリーン・ピロロ,シュ・リアン,ウィリアム・アレキサンダー

申请号：

JP2000582581

公开号：

JP5448283B2

申请日:

1999.11.19

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

The present invention relates to gene transfer and gene therapy technology. More specifically, the invention provides compositions and methods for targeted virus delivery. The method utilizes a method of mixing the virus, which may be a recombinant virus which will express a protein of interest or a nucleic acid of interest, with a cell-targeting ligand, e.g., transferrin. The virus and ligand are mixed without crosslinkers or agents which would covalently bond the virus and ligand. This simple mixing causes less inactivation than chemically linking the ligand to the virus and therefore results in a more active therapeutic composition than obtained by methods which utilize crosslinking agents.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/