Michael John Bradley Kutryk;Robert J. Cottone, Jr.;Stephen M. Rowland
发明人:
Michael John Bradley Kutryk,Robert J. Cottone, Jr.,Stephen M. Rowland
申请号：
US11119291
公开号：
US09364565B2
申请日:
2005.04.29
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Therapeutic and drug delivery systems are provided in the form of medical devices with coatings for capturing and immobilizing target cells such as circulating progenitor or genetically-altered mammalian cells in vivo. The genetically-altered cells are transfected with genetic material for expressing a marker gene and at least one therapeutic gene in a constitutively or controlled manner. The marker gene is a cell membrane antigen not found in circulating cells in the blood stream and therapeutic gene encodes a peptide for the treatment of disease, such as, vascular disease and cancer. The coating on the medical device may be a biocompatible matrix comprising at least one type of ligand, such as antibodies, antibody fragments, other peptides and small molecules, which recognize and bind the target cells. The therapeutic and/or drug delivery systems may be provided with a signal source such as activator molecules for stimulating the modified cells to express and secrete the desired marker and therapeutic gene products.
