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PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF HEPATITIS C
专利权人:
Ф. ХОФФМАНН-ЛЯ РОШ АГ (CH)
发明人:
ЛАЙМИНЕР Андреас (DE),ЛИНДЕНСТРУТ Кай (DE),МИЛЛЕР Дейв Алан (US),ШОЙБЕЛЬ Эммануэль (FR),ШАХ Навнит Харговиндас (US)
申请号:
RU2013125339/15
公开号:
RU2013125339A
申请日:
2011.11.07
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A granular pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof and at least one poloxamer. The composition of claim 1, wherein the at least one poloxamer is poloxamer 188.3. The composition according to claim 1, further comprising an intragranular excipient, preferably selected from the group consisting of dicalcium phosphate, calcium sulfate, lactose, cellulose, kaolin, mannitol, sodium starch chloride and powdered sugar. The composition of claim 3, wherein the intragranular excipient is beckoning, preferably in amounts of up to 80% by weight, and more preferably in amounts of up to 40% by weight. The composition according to claim 1, comprising from 20 to 50% by weight of the compounds of formula (I) and from 20 to 40% by weight of poloxamer 188.6. The composition according to claim 5, comprising 40% by weight of the compounds of formula (I) and 23% by weight of poloxamer 188.7. A composition according to claim 6, comprising 40% by weight of the compound of formula (I) and 23% by weight of poloxamer 188 and 37% by weight of mannitol. The composition according to claim 1, which is a binary composition consisting of a compound of formula (I) from 20 to 80% by weight and poloxamer from 20 to 80% by weight, and preferably from a compound of formula (I) from 40 to 60% by weight and poloxamer from 40 to 60% by weight. 9. The composition according to claim 1, obtained by extrusion from a hot melt. A composition according to any one of claims 1 to 9, wherein the compound of formula (I) is present in crystalline form. A dosage form for oral administration containing a composition according to any one of claims 1 to 9.12. The oral dosage form of claim 10, further comprising at least one excipient selected from the group comprising excipients, binders, disintegrants, lubricants, release agents1. Гранулярная фармацевтическая композиция, содержащая соединение формулы (I)или его фармацевтически приемлемую соль и по ме
来源网站:
中国工程科技知识中心
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