Иващенко Александр Васильевич (RU),Иващенко Андрей Александрович (RU),Бычко Вадим Васильевич (US),Хват Александр Викторович (US),Савчук Николай Филиппович (RU),Роговой Борис (US)
申请号：
RU2015104888
公开号：
RU2015104888A
申请日:
2015.02.13
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. Inhibitors of replication of hepatitis B virus, which are quinoxaline-6-carboxamides of the general formula 1, their pharmaceutically acceptable salts and / or gidratygde Ar, Ari Arpredstavlyayut an optionally identical substituents selected from phenyl optionally substituted with one, two or three identical or different, substituents selected from C-alkyl, methoxy, and halogen pyridyl furyl tetragidrofurila.2. Inhibitor according to Claim. 1, which is a quinoxaline-6-carboxamide, selected from a number of compounds of Formula 1.1-1.103. A pharmaceutical composition in the form of tablets, capsules, or injections, placed in pharmaceutically acceptable packing intended for treatment of hepatitis B containing the replication of hepatitis C virus inhibitor in the general formula of claim 1. 1, its pharmaceutically acceptable salt and / or hydrate thereof in a therapeutically effective kolichestve.4. A process for preparing a pharmaceutical composition by mixing with the inert filler and / or diluent, at least one inhibitor of general formula 1 according to Claim. 1 or a pharmaceutically acceptable salt and / or hydrate thereof in a therapeutically effective kolichestve.5. Method for the prophylaxis and treatment of hepatitis B virus, comprising administering to the patient a replication inhibitor of hepatitis B virus of general formula 1 according to Claim. 1, its pharmaceutically acceptable salt and / or hydrate thereof or a pharmaceutical composition according to claim. 3, comprising as an active ingredient, at least one inhibitor of hepatitis C virus replication in the general formula of claim 1. 1, its pharmaceutically acceptable salt and / or gidrat.6. A method of inhibiting HCV activity in in vivo comprising the step of contacting an inhibitor of the general formula according to claim 1. 1, an1. Ингибиторы репликации вируса гепатита В, представляющие собой хиноксалин-6-карбоксамиды общей формулы 1, их фармацевтически приемлемые соли и/или гидратыгде Ar1, Ar2 и
