Gopi M. Venkatesh;Jin-Wang Lai;Vijaya Swaminathan;James M. Clevenger
发明人:
Gopi M. Venkatesh,Vijaya Swaminathan,Jin-Wang Lai,James M. Clevenger
申请号：
US13310632
公开号：
US20120282335A1
申请日:
2011.12.02
申请国别(地区):
US
年份:
2012
代理人:
摘要：
This invention relates to rapidly dispersing microgranules comprising at least one sugar alcohol or saccharide, at least one super disintegrant, and a pharmaceutically acceptable additive with multi-functionality (e.g., starch acting as a binder, disintegrant, diluent/filler, glidant, etc) at a low level, which can be formed by not only eliminating a wet milling step but also avoiding an extensive dry milling step. Furthermore, such rapidly dispersing microgranules could also comprise a pharmaceutically active agent thereby providing for a pharmaceutical composition, or the rapidly dispersing microgranules thus produced are suitable for blending with a pharmaceutically active agent that is optionally taste-masked and/or controlled release coated microparticles to also provide for a pharmaceutical composition and the invention is also directed to a method for manufacturing such rapidly dispersing microgranules in a high useable yield, as well as orally disintegrating tablets comprising such rapidly dispersing microgranules. The rapidly dispersing microgranules are also free flowing.
