VENKATESH GOPI M,SWAMINATHAN VIJAYA,LAI JIN-WANG,CLEVENGER JAMES M
申请号：
IN4476/CHENP/2013
公开号：
IN2013CN04476A
申请日:
2013.06.11
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
This invention relates to rapidly dispersing microgranules comprising at least one sugar alcohol or saccharide at least one super disintegrant and a pharmaceutically acceptable additive with multi functionality (e.g. starch acting as a binder disintegrant diluent/filler glidant etc) at a low level which can be formed by not only eliminating a wet milling step but also avoiding an extensive dry milling step. Furthermore such rapidly dispersing microgranules could also comprise a pharmaceutically active agent thereby providing for a pharmaceutical composition or the rapidly dispersing microgranules thus produced are suitable for blending with a pharmaceutically active agent that is optionally taste masked and/or controlled release coated microparticles to also provide for a pharmaceutical composition and the invention is also directed to a method for manufacturing such rapidly dispersing microgranules in a high useable yield as well as orally disintegrating tablets comprising such rapidly dispersing microgranules. The rapidly dispersing microgranules are also free flowing.
