Andrew Wolff;Cytokinetics, Inc.;Fady Malik;Jesse Cedarbaum;John Mao
发明人:
Cedarbaum, Jesse,Mao, John,Malik, Fady,Wolff, Andrew A.
申请号：
AU2012281042
公开号：
AU2012281042A1
申请日:
2012.07.12
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
Provided is a method for treating ALS in a subject, comprising administering to the subject a therapeutically effective amount of riluzole and a therapeutically effective amount of CK-2017357. Also provided are methods of reducing the variability of riluzole exposure (e.g., Cmax and/or AUC24h) in a subject, methods of reducing the variability of riluzole exposure (e.g., Cmax and/or AUC24h) between two or more subjects, methods of decreasing the total daily dose of riluzole in a subject, methods of increasing the half-life of riluzole in a subject, methods for decreasing the frequency of riluzole dosing in the subject, and methods for reducing the incidence and/or severity of adverse events in a subject treated with riluzole.
