Jeremy E. Wulff,Michael G. Brant,Jeremy W. Mason,Caleb M. Bromba,Martin J. Boulanger
申请号：
US13586687
公开号：
US08883846B2
申请日:
2012.08.15
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Disclosed embodiments concern the synthesis and use of therapeutic compounds that for treating emerging flu strains and minimizing resistance to such strains. Methods for making the disclosed compounds concern using a base-mediated addition/cyclization sequence followed by functional group manipulation to develop functionalized compounds that can target neuraminidase, which makes them ideal candidates for treating influenza. Pharmaceutical compositions comprising the therapeutic compounds and biologically-acceptable materials are also described. Methods of inhibiting neuraminidase in subjects that are suspected of containing neuraminidase are also described. The use of metabolites of the disclosed compounds can also be used in diagnostic assays for therapeutic dosing of the disclosed compounds.
