Cielens, Indulis,Meijerink, Edwin,Bachmann, Martin F.,Tissot, Alain,Maurer, Patrick,Storni, Tazio,Renhofa, Regina,Pumpens, Paul,Lipowsky, Gerad,Schwarz, Katrin
申请号：
AU2009200115
公开号：
AU2009200115B2
申请日:
2009.01.09
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2009200115B220120503.pdf#####Packaging of Immunostimulatory Substances Into Virus-Like Particles: Method of Preparation and Use Abstract Of The Disclosure 5 The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs). Such CpGVLPs are dramatically more immunogenic than their CpG-free counterparts 10 and induce enhanced B and T cell responses. The immune response against antigens optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself In addition, the T cell responses against both the VLPs and antigens are especially directed to the Th1 type. Antigens attached to CpG-loaded VLPs may therefore be 15 ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases. 20 Ref: P23715AU00
