VAN SNICK, Jacques,VAN SNICK JACQUES,UYTTENHOVE, Catherine,UYTTENHOVE CATHERINE,BOON, Thierry,BOON THIERRY
申请号：
ES13758033
公开号：
ES2694203T3
申请日:
2013.03.06
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
Specific binding members, particularly antibody and its segment, bind to transforming growth factor beta 1 (TGF-β 1) particularly provide the identification mankind and mouse TGF-β 1 and TGF-β 2 or the TGF-β 3 do not recognized or bound. Specific antibodies provided by the invention specific recognition and can neutralize TGF-β 1. These antibody can be used for diagnosing and it is conditions associated be activated or raised TGF-β 1, including cancer, and for adjusting immunocyte and immune response, including immune response and cancer or cancer antigen. The anti-TGF- beta 1 antibodies, the CDR of variable region or the sequence in domain and its segment can be used for treatment combine chemotherapeutics, immunomodulator or anticancer agent and/or with other antibody or its segment. This demonstration antibody is by novel antibodies, including antibody 13A1, whose sequence present invention.
