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Process for producing a composition of engineered T cells
专利权人:
Juno Therapeutics; Inc.
发明人:
MUJACIC, Mirna,RAHARDJO, Ayu,BEAUCHESNE, Pascal,KHUU-DUONG, Kien,AIFUWA, Ivie,CHAN, Calvin
申请号:
AU2018379092
公开号:
AU2018379092A1
申请日:
2018.12.07
申请国别(地区):
AU
年份:
2020
代理人:
摘要:
The present disclosure provides methods for genetically engineering T cells, such as CD4+ T cells and/or CD8+ T cells, for use in cell therapy. In some aspects, the provided methods include one or more steps for pooling enriched CD4+ and CD8+ cells, such as at a 1: 1 ratio, and then incubating the cells under stimulating conditions, introducing a recombinant polypeptide to the cells through transduction or transfection, and/or cultivating the cells under conditions that promote proliferation and/or expansion. In some aspects, the provided methods are an efficient, reliable means to produce genetically engineered T cells with a high degree of success.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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