Optional water channel protein inhibitor, such as -2 inhibitor of aquaporin protein-4 or aquaporin, such as some phenyl benzoyl amine compounds are provided in treatment or prevention graft rejection and for the purposes during openheart surgery in Cardioprotective. Optional water channel protein inhibitor, such as aquaporin protein-4 (AQP4) or (AQP2) inhibitor of aquaporin -2 are provided in treatment or prevention graft rejection and for the purposes during openheart surgery in Cardioprotective.
