The present invention relates to an X-ray detector and the pixel layout. In order to provide a facilitated way of avoiding artifacts in images provided by X-ray detectors, an X-ray detector (10) is provided, comprising a pixel array (12) with a plurality of pixels (14), each of which comprises a sensitive area (16), a body structure (18),and an electric circuitry (20). The sensitive areas are attached to the body structure and the electric circuitry is provided to control and read out the sensitive areas and to connect the sensitive areas with a processing unit. The sensitive areas are configured to provide an electric signal representing X-ray radiation hitting the pixel. All pixels are provided in a pixel layout with a pixel layout scheme (22) where the sensitive area is a first part (24) of the pixels surface that is contributing to the pixels signal and a second part (26) of the pixels surface is irrelevant to contributing to the pixels signal. The sensitive areas are arranged on the body structure in a pattern (30) in which at least a part of the pixels having the same pixel layout scheme is provided such that the pixel layout of adjacent pixels is arranged differently.
