VAN DE WINKEL JAN NETHERLANDS,VINK TOM NETHERLANDS,SCHUURMAN JANINE NETHERLANDS,PARREN PAUL NETHERLANDS,AALBERSE ROB NETHERLANDS,VAN DER NEUT KOLFSCHOTEN MARIJN NETHERLANDS
申请号：
IN7495/CHENP/2009
公开号：
IN299537B
申请日:
2008.05.30
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
The present invention relates to stabilized IgG4 antibodies, to methods of producing such antibodies and to uses of such antibodies as a medicament. In a main aspect, the invention relates to a stabilized IgG4 antibody, comprising a heavy chain and a light chain, wherein said heavy chain comprises a human IgG4 constant region having a substitution of the Arg residue at position (409), the Phe re sidue at position (405) or the Lys residue at position (370). WO2008145142A1
