SCHUURMAN, JANINE,PARREN, PAUL,VAN DER NEUT KOLFSCHOTEN, MARIJN,VINK, TOM,VAN DE WINKEL, JAN,AALBERSE, ROB
申请号：
AU2008255352
公开号：
AU2008255352B2
申请日:
2008.05.30
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The present invention relates to stabilized IgG4 antibodies, to methods of producing such antibodies and to uses of such antibodies as a medicament. In a main aspect, the invention relates to a stabilized IgG4 antibody, comprising a heavy chain and a light chain, wherein said heavy chain comprises a human IgG4 constant region having a substitution of the Arg residue at position (409), the Phe re sidue at position (405) or the Lys residue at position (370).
