Jan VAN DE WINKEL,Tom VINK,Janine SCHUURMAN,Paul PARREN,Rob AALBERSE,Marijn VAN DER NEUT KOLFSCHOTEN
申请号：
US15197496
公开号：
US20170029521A1
申请日:
2016.06.29
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to stabilized IgG4 antibodies, to methods of producing such antibodies and to uses of such antibodies as a medicament. In a main aspect, the invention relates to a stabilized IgG4 antibody, comprising a heavy chain and a light chain, wherein said heavy chain comprises a human IgG4 constant region having a substitution of the Arg residue at position (409), the Phe residue at position (405) or the Lys residue at position (370).
