胺基唍、胺基硫唍及胺基-1,2,3,4-四氫喹啉衍生物，包含彼等之醫藥組合物及彼等於治療之用途农业专利-农业学术服务平台

发明人:: AMBERG, WILHELM,艾姆柏格　威惠牡,POHLKI, FRAUKE,普基　法罗克,普基　法羅克,LANGE, UDO,兰吉　伍杜,蘭吉　伍杜,WANG, YING,王　颖,王　穎,ZHAO, HONGYU,赵　红宇,趙　紅宇,LI, HUAN-QIU,李　焕秋,李　煥秋,BREWER, JASON,布鲁尔　杰森,布魯爾　傑森,VASUDEVAN, ANIL,维苏德泛　,艾姆柏格威惠牡,普基法罗克,普基法羅克,兰吉伍杜,蘭吉伍杜,王颖,王穎,赵红宇,趙紅宇,李焕秋,李煥秋,布鲁尔杰森,布魯爾傑森,维苏德泛

摘要：: The present invention relates to aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives of the formula (I) or a physiologically tolerated salt thereof.The invention relates to pharmaceutical compositions comprising such aminochromane, aminothi-ochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, and the use of such aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives for therapeutic purposes. The aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives are GlyT1 inhibitors.本發明係關於式(I)之胺基唍、胺基硫唍及胺基-1,2,3,4-四氫喹啉衍生物：或其生理上可耐受之鹽。本發明係關於包含該等胺基唍、胺基硫唍及胺基-1,2,3,4-四氫喹啉衍生物之醫藥組合物，及該等胺基唍、胺基硫唍及胺基-1,2,3,4-四氫喹啉衍生物用於治療目的之用途。該等胺基唍、胺基硫唍及胺基-1,2,3,4-四氫喹啉衍生物為GlyT1抑制劑。