The purpose of the invention is to provide a composition that has high biological safety and contributes to the inhibition of FOXO1 activity. Also, the purpose of the invention is to provide a use for said composition for inhibiting FOXO1 activity and a method for inhibiting FOXO1 activity. It was found that a specific compound, among naturally occurring compounds, has a FOXO1 activity inhibitory action. The invention provides a novel and effective means contributing to suppressing muscular atrophy, promoting muscle synthesis, and suppressing a reduction in bone density.本發明係以提供一種生物安全性高，賦予FOXO1活性之阻礙的組成物為目的。又，提供欲阻礙FOXO1活性之組成物的使用，及阻礙FOXO1活性的方法為目的。 本發明為發現由來自天然物的化合物之中的特定化合物為具有FOXO1活性之阻礙作用。本發明為提供一種對於肌肉萎縮抑制、肌肉合成促進及骨密度降低抑制有貢獻的有效果且新穎的方法。
