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Polymer conjugate of folic acid or folic acid derivative
专利权人:
Takeshi Nakanishi
发明人:
Takeshi Nakanishi,Kazuhisa Hara,Chieko Seno
申请号:
US12991041
公开号:
US09149540B2
申请日:
2009.04.28
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Disclosed is a polymer conjugate of folic acid or a folic acid derivative, wherein an amide bond is not used. The compound has chemical stability and adequate drug release rate in the living organism. Specifically disclosed is a polymer conjugate of folic acid or a folic acid derivative, wherein a substituent represented by formula (I) is bonded to a carboxy group of a block copolymer which is composed of a polyethylene glycol and a polymer having a carboxy group in a side chain, or a pharmacologically acceptable salt thereof.[In the formula, A represents a monocyclic or fused aromatic group G represents an optionally substituted (C1-C6) alkylene group Y represents a hydrogen atom or a substituent and E represents a residue of folic acid or a folic acid derivative.]
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