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Polymer conjugate of folic acid or folic acid derivative
专利权人:
日本化薬株式会社
发明人:
中西 健,原 和久,瀬野 千恵子
申请号:
JP2010511053
公开号:
JP5366940B2
申请日:
2009.04.28
申请国别(地区):
JP
年份:
2013
代理人:
摘要:
Disclosed is a polymer conjugate of folic acid or a folic acid derivative, wherein an amide bond is not used. The compound has chemical stability and adequate drug release rate in the living organism. Specifically disclosed is a polymer conjugate of folic acid or a folic acid derivative, wherein a substituent represented by formula (I) is bonded to a carboxy group of a block copolymer which is composed of a polyethylene glycol and a polymer having a carboxy group in a side chain, or a pharmacologically acceptable salt thereof. [In the formula, A represents a monocyclic or fused aromatic group; G represents an optionally substituted (C1-C6) alkylene group; Y represents a hydrogen atom or a substituent; and E represents a residue of folic acid or a folic acid derivative.]
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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