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Inhibitors of folic acid-dependent enzymes
专利权人:
Dan Stoicescu
发明人:
Dan Stoicescu
申请号:
US12796481
公开号:
US08518954B2
申请日:
2010.06.08
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The invention relates to compounds of the formula I, or pharmaceutically acceptable salts thereof:wherein: Z=O or S n=1-3 R3=—CO2R8, —C(O)SR8, —C(O)NHR8, —C(S)OR8, —C(S)SR8, —C(S)NHR8, —C(NH)SR8 or —C(NH)NHR8, wherein R8 is —H or alkyl R4=—H, —CH2R5 or —CH2CH2R5, wherein R5 independently has one of the meanings of R3 B=—NR2—, —CH2NR2—, —CH2CH2NR2—, —CH2CHR7— or —CH2O—, wherein R2 is H or a C1-3 alkyl, alkenyl or alkynyl group, and R7 is H or a C1-3 alkyl or alkoxy group A=wherein R1=—NH2 or —OH, and C and D are each, independently, a 5- or 6-membered, substituted or unsubstituted, aromatic or non-aromatic ring which may also contain one or more heteroatoms, and C is connected to group B in any available position.
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