MEERPOEL, LIEVEN,BACKX, LEO JACOBUS JOZEF,JAROSKOVA, LIBUSE,ROEVENS, PETER WALTER MARIA,VAN DER VEKEN, LOUIS JOZEF ELISABETH,VIELLEVOYE, MARCEL,LINDERS, JOANNES THEODORUS MARIA
申请号：
CA2558506
公开号：
CA2558506C
申请日:
2005.03.07
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention is concerned with novel aryl piperidine or piperazinecompounds substituted with certain 5-membered heterocycles having apoBsecretion/MTP inhibiting activity and concomitant lipid lowering activity. Theinvention further relates to methods for preparing such compounds,pharmaceutical compositions comprising said compounds as well as the use ofsaid compounds as a medicine for the treatment of hyperlipidemia, obesity andtype II diabetes (Formula (I)). The invention further relates to methods forpreparing such compounds, pharmaceutical compositions comprising saidcompounds as well as the use of said compounds as a medicine for the treatmentof atherosclerosis, pancreatitis, obesity, hyper~triglyceridemia,hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes.
