Polypeptide production method by association control

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专利权人:

中外製薬株式会社

发明人:

井川 智之,角田 浩行

申请号：

JP2007511155

公开号：

JP5620626B2

申请日:

2006.03.31

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

In the course of the present invention, it was discovered that one could regulate association between polypeptides by modifying amino acid residues that form the interface during the association to amino acids carrying the same type of charge. In this context, the present invention enables efficient formation of heterologous molecules. For example, the present invention can be suitablyapplied to the preparation of bispecific antibodies.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/