METHODS FOR PRODUCING POLYPEPTIDES BY REGULATING POLYPEPTIDE ASSOCIATION

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专利权人:

发明人:

申请号：

EP06730751.2

公开号：

EP1870459B1

申请日:

2006.03.31

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

In the course of the present invention, it was discovered that one could regulate association between polypeptides by modifying amino acid residues that form the interface during the association to amino acids carrying the same type of charge. In this context, the present invention enables efficient formation of heterologous molecules. For example, the present invention can be suitablyapplied to the preparation of bispecific antibodies.

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