Methods for producing polypeptides by regulating polypeptide association

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专利权人:

Tomoyuki Igawa

发明人:

Tomoyuki Igawa,Hiroyuki Tsunoda

申请号：

US11910128

公开号：

US10011858B2

申请日:

2006.03.31

申请国别(地区):

US

年份:

2018

代理人:

摘要：

In the course of the present invention, it was discovered that one could regulate association between polypeptides by modifying amino acid residues that form the interface during the association to amino acids carrying the same type of charge. In this context, the present invention enables efficient formation of heterologous molecules. For example, the present invention can be suitably applied to the preparation of bispecific antibodies.

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