SYNTHESE ET EVALUATION DE NOUVELLES SUBSTANCES MIMETIQUES DE PHTHALIMIDE COMME AGENTS ANTIANGIOGENESE

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专利权人:

UNIVERSITY OF VIRGINIA PATENT FOUNDATION

发明人:

BROWN, MILTON L.

申请号：

CA2444704

公开号：

CA2444704C

申请日:

2002.04.22

申请国别(地区):

CA

年份:

2012

代理人:

摘要：

The present invention is directed to novel thalidomide derivative compoundsthat have activity as anti-angiogenic compounds. More particularly thecompounds have the general structure: where R1 is selected from the groupconsisting of H, halo, alkyl, haloalkyl, -NH2, hydroxy and alkoxy； R2 isselected from the group consisting of optionally substituted bicyclic,optionally substituted aryl, and R6 is H, or C1-C8 alkyl； R19 is optionallysubstituted aryl； and m is 0-6.

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