PARK, Sung Hee,KIM, Hyun Uk,LIM, Chang Ki,KWON, Se Chang,JUNG, Sung Youb,HWANG, Sang Youn,OH, Euh Lim
申请号：
CL2016001844
公开号：
CL2016001844A1
申请日:
2016.07.20
申请国别(地区):
CL
年份:
2017
代理人:
摘要：
This paper introduces a combination of a similar insulin and a biological adaptive material, including SCCPs similar to that of SEC 37 A represented by Formula 1, while sec 38 B chain and biological adaptive material represented by formula 2 are selected from polyethylene glycol and fatty acid. Cholesterol, albumin and a part thereof, a peptide or protein related to albumin, an antibody, an antibody, a polypeptide, including an immunoglobulin in Fc region, a nucleic acid, cellulose, transfer agent, Sagan, polypropylene glycol,an ethylene glycol propylene glycol copolymer, polyoxyethylated polyols, polyvinyl alcohols, dextran, polyvinyl ether, PLA polylactic acid, polygalactic glycolic acid PLGA, lipid polymers, chitins, hyaluronic acid, and a combination thereof where the Formula where is Xaa1-Xaa2-Val-Glu-Gln-Cys-Cys-Thr-Ser-Ile-Cys-Ser-Leu-Xaa3-Gln-Leu-Glu-Asn-Xaa4-Cys-Asn SEQ ID No. 37 and Formula 2 is Phe-Val-Asn-Gln-His-Leu-Cys-Xaa5-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg-Xaa6-Xaa7-Xaa8- Tyr-Thr-Pro-Lys-Thr SEQ ID No. 38, where in Formula 1 it is Xaa1 is alanine, Xaa2 is isoleucine, Xaa3 is tyrosine, and Xaa4 is tyrosine and Formula 2, Xaa5 is glycine,Xa6 is glycerin, Xa7 is phenyllanin, xa8 is similar to phenyllanin, No. 1, section ID 20 is a method for preparing this mixture, which includes combining similar insulin with bioactive substances, drug ingredients including this mixture and a vehicle acceptable on the drug, and a mixture using the pairing method. Effective drugs for diabetes.Se describe un conjugado de un análogo de insulina y un material biocompatible que comprende el análogo de insulina de cadena A de la SEC ID Nº 37 representada por la Fórmula 1, y la cadena B de la SEC ID Nº 38 representada por la Fórmula 2 y el material biocompatible es seleccionado del grupo que consiste de polietilen glicol, ácido graso, colesterol, albúmina y un fragmento de la misma, un péptido o una proteína que tiene una afinidad de unión a albúmina, un
