SE CHANG KWON,IN YOUNG CHOI,HYUNG KYU LIM,JONG SOO LEE,EUH LIM OH,JIN YOUNG KIM
申请号：
ARP160102602
公开号：
AR105822A1
申请日:
2016.08.25
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
Claim 1: a Peptide Analogue of insulin involves a Chain of SEQ ID no. 3 shown in the General formula (1) and a B Chain of SEQ ID no. 4 indicated in the General formula (2),(General formula (1): GLY ile Val Glu GLN Cys - Cys THR - Ile CYS XAA ser Leu - Leu - g1n Glu ASN Tyr CYS ASN (SEQ ID no. 3) where XAA is glutamic acid or asparagine； and General formula (2): PHE Val ASN GLN his Leu CYS Gly ser his Glu ala Val Leu - Leu - Leu Val Tyr CYS Gly Glu ARG Gly PHE XAA Tyr - - t HR pro Lys THR (SEQ ID no. 4) where XAA is phenylalanine or is deleted.Claim 8: a Nucleic Acid encoding the Peptide Analogue insulin according to any one of claims 1 to 7. 11: Transforming a claim which is transformed with the recombinant expression vector according to claim 10.Claim 13: a method to prepare the Peptide Analogue insulin according to claim 1,Comprising: (a) preparation of a recombinant expression vector comprising a Nucleic Acid encoding the Peptide Analogue insulin according to claim 1； (b) the processing of the recombinant expression vector in a host cell and obtain a T The same ransformante； (c) the cultivation of Transforming and the expression of the Peptide insulin Analogue； and (d)Isolation and purification of the expressed Peptide insulin Analogue. Claim 17: a Pharmaceutical composition for the treatment of Diabetes comprising the Peptide Analogue insulin according to any one of claims 1 to 7 and a pharmaceutically acceptable Carrier.Reivindicación 1: Un péptido análogo de insulina que comprende una cadena A de SEQ ID Nº 3 indicada en la fórmula general (1) y una cadena B de SEQ ID Nº 4 indicada en la fórmula general (2), (fórmula general 1): Gly-Ile-Val-Glu-Gln-Cys-Cys-Thr-Ser-Ile-Cys-Ser-Leu-Xaa-G1n-Leu-Glu-Asn-Tyr-Cys-Asn (SEQ ID Nº 3) en donde Xaa es ácido glutámico o asparragina； y (fórmula general 2): Phe-Val-Asn-Gln-His-Leu-Cys-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg-Gly-Phe-Xaa-Tyr-Thr-Pro-Lys-Thr (SEQ ID Nº 4) en donde Xaa es fenilalanina o está
