A syringe device includes a syringe barrel and piston having a fluidpassageway extending from a vial port. Another syringe device includes asyringe barrel, a piston sleeve and an insert. A channel extends along a sideof the insert. A valve controls fluid communication between the channel andthe syringe barrel. Another syringe device has a syringe barrel, a pistonsleeve and an insert. A valve controls fluid communication between acompartment within the insert and the syringe barrel. A method of preparing amedication includes providing a component within a syringe barrel and anothercomponent within a compartment of a piston insert. A seal is over-molded ontoa tip of the insert and an end of a piston sleeve. The sleeve is rotatedrelative to the insert to establish fluid communication between thecompartment and the barrel chamber.
