A syringe device includes a syringe barrel and piston having a fluid passagewayextending from a vial port. Another syringe device includes a syringe barrel,a piston sleeve and an insert. A channel extends along a side of the insert. A valvecontrols fluid communication between the channel and the syringe barrel. Anothersyringe device has a syringe barrel, a piston sleeve and an insert. A valve controlsfluid communication between a compartment within the insert and the syringebarrel. A method of preparing a medication includes providing a component withina syringe barrel and another component within a compartment of a piston insert.A seal is over-molded onto a tip of the insert and an end of a piston sleeve. The sleeveis rotated relative to the insert to establish fluid communication between thecompartment and the barrel chamber.
