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Tetrahydropyran derivatives against neurological diseases
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
KOLCZEWSKI, SABINE,PINARD, EMMANUEL
申请号:
ES11700964
公开号:
ES2511071T3
申请日:
2011.01.28
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
Compound of general formula: ** Formula ** in which: R1 / R2 are, independently, hydrogen, a saturated or partially saturated (CR2) o-cycloalkyl selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl , cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cycloheptenyl, optionally substituted with C1-7 alkyl or hydroxy or are C1-7 alkyl or heterocycloalkyl with a saturated or partially saturated ring containing between 3 and 6 carbon atoms, selected from the group consisting of piperazinyl, pyrrolidinyl, oxetanyl, morpholinyl, piperidinyl or tetrahydropyranyl, I is 0 or 1, and R can be the same or different and is hydrogen or C1-7 alkyl, or R1 and R2 can form together with the atom of N at which are attached a heterocycloalkyl group, selected from the group consisting of pyrrolidinyl, piperidinyl, 3-azabicyclo [3.1.0] hex-3-yl or 2-aza-bicyclo [3.1.0] hex-2-yl, which are optionally replaced With hydroxy, R 3 is S-C 1-7 alkyl, C 1-7 alkyl, C 1-7 alkoxy or a saturated or partially saturated C 3-7 cycloalkyl selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl or cycloheptenyl, R3 'is hydrogen, halogen substituted C1-7 alkyl, C1-7 alkyl or C1-7 alkoxy, R4 is halogen substituted C1-7 alkyl, C1-7 alkyl or C1-7 alkoxy, X is -O- or -CH2-, X 'is -O- or -CH2-, provided that one of X or X' is always -O- and the other is -CH2-, or an addition salt of Pharmaceutically acceptable acid, a racemic mixture or its corresponding enantiomer and / or optical isomer thereof.Compuesto de fórmula general:**Fórmula** en la que: R1/R2 son, independientemente, hidrógeno, un (CR2)o-cicloalquilo C3-7 saturado o parcialmente saturado seleccionado de entre el grupo que consiste de ciclopropilo, ciclobutilo, ciclopentilo, ciclopentenilo, ciclohexilo, ciclohexenilo, cicloheptilo, cicloheptenilo, sustituidos opcionalemnte con alquilo C1-7 o hidroxi o son alquilo C1-7 o heterocicloalquilo con un anillo sa
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