A surgical instrument includes an end effector, a handle assembly, a knife drive assembly, an electrode activation assembly, and a lockout assembly. The end effector includes a first jaw, a second jaw, a knife, and an electrode assembly. The handle assembly includes a housing associated with the first jaw and an arm associated with the second jaw, where the arm is configured to pivot the second jaw between an open position and a closed position. The lockout assembly is may transition between a locked configuration and an unlocked configuration. The lockout assembly may prevent activation of the electrode and prevent actuation of the knife drive assembly while in the locked configuration. The lockout assembly may allow activation of the electrode and allow actuation of the knife drive assembly while in the unlocked configuration.
