A surgical clip applier, comprising: a housing a pair of handles pivotably connected to opposite sides of the housing a channel assembly fixed to and extending from the housing a clip carrier disposed within said channel assembly and defining a channel a drive channel slidably disposed within at least one of said housing and said channel assembly, said drive channel having a first end operatively connected to at least one of said handles and a second end configured and dimensioned to selectively engage a pair of jaws to effectuate closure of said pair of jaws a plurality of clips slidably disposed within said channel of said clip carrier a clip follower slidably disposed within said channel of said clip carrier at a location proximal of said plurality of clips and a lockout disposed in a distal end of said channel assembly, wherein said lockout is actuated by said clip follower when a last clip is expelled from said clip applier, wherein a tab of said clip follower engages against said lockout to urge said lockout to extend across a path of said drive channel, thereby preventing said drive channel from moving distally.
