CHAPPIE, THOMAS ALLEN,奇彼 汤玛斯,奇彼 湯瑪斯,GALATSIS, PAUL,格拉西斯 保罗,格拉西斯 保羅,GARNSEY, MICHELLE RENEE,甘西 蜜雪儿,甘西 蜜雪兒,HELAL, CHRISTOPHER JOHN,海拉 克里斯多夫,HENDERSON, JACLYN LOUISE,韩德森 贾克琳,韓德森 賈克琳,KORMOS, BETH
申请号：
TW107107733
公开号：
TWI675826B
申请日:
2018.03.07
申请国别(地区):
TW
年份:
2019
代理人:
摘要：
The present invention provides novel cyclic substituted imidazo[4,5-c]quinoline derivatives of Formula I, and the pharmaceutically acceptable salts thereof wherein R1, R2, R4, R5, R6, X and Z are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising the compounds of Formula I and to use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases including Parkinson’s disease or Alzheimer’s disease, cancer, Crohn’s disease or leprosy.本發明提供新穎式(I)之環狀經取代之咪唑并[4,5-c]喹啉衍生物，及其醫藥上可接受的鹽 其中，R1、R2、R4、R5、R6、X及Z係如說明書中所定義。本發明亦針對包含式I之化合物的醫藥組成物，及化合物於治療與LRRK2相關的疾病之用途，例如神經退化性疾病(包含巴金森氏症或阿茲海默症)、癌症、克隆氏症或麻瘋。
