具有脲結構的稠環化合物农业专利-农业专业知识服务系统

专利权人:: DAIICHI SANKYO COMPANY, LIMITED;SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

发明人:: NAKAMURA, TSUYOSHI,中村毅,AKIU, MAYUKO,秋生麻由子,TSUJI, TAKASHI,辻贵司,辻貴司,TANAKA, JUN,田中纯,田中純,TERAYAMA, KOJI,寺山浩司,YOKOYAMA, MIKA,横山美香,橫山美香,PINKERTON, ANTHONY B.,品克顿　安东尼Ｂ,品克頓　安東尼Ｂ,SESSIONS, EDWAR

摘要：: The present invention relates to a novel fused ring compound having urea structure that exhibits excellent NAMPT activating effect, and a method using the same for treating / preventing metabolic disorder, cardiovascular and kidney disease, mitochondrial disease, neurodegenerative disease, ocular disease, and muscle wasting disorder.The present invention provides a compound represented by following formula (I) or a pharmacologically acceptable salt:wherein A, B, R1, R2and R3represent the same meanings as in the claims.本發明係關於一種新穎稠環化合物，其具有展現優異NAMPT活化作用的脲結構；且關於一種使用其的方法，其係用於治療/預防代謝失調、心血管和腎臟疾病、粒線體疾病、神經退化性疾病、眼部疾病及肌肉消瘦症。本發明提供一種下式(I)所表示之化合物或醫藥上可接受之鹽類：其中A、B、R1、R2及R3表示與申請專利範圍中相同的意義。