調節細胞凋亡信號之激酶的抑制劑农业专利-农业学术服务平台

发明人:: CORKEY, BRITTON,柯奇　布莱顿,柯奇　布萊頓,GRAUPE, MICHAEL,葛罗　麦可,葛羅　麥可,KOCH, KEITH,寇奇　济慈,寇奇　濟慈,MELVIN, LAWRENCE S.,梅尔文　罗伦斯,梅爾文　羅倫斯,NOTTE, GREGORY,诺特　葛雷高瑞,諾特　葛雷高瑞,柯奇布莱顿,柯奇布萊頓,葛罗麦可,葛羅麥可,寇奇济慈,寇奇濟慈,梅尔文罗伦斯,梅爾文羅倫斯,诺特葛雷高瑞,諾特葛雷高瑞

摘要：: The present invention relates to compounds of Formula (I): wherein X1, X2, X3, X4, X5, X6, X7, X8, R1, R2, R3 are as defined above. The compounds have apoptosis signal-regulating kinase (“ASK1”) inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases. The invention also relates to pharmaceutical compositions comprising one or more of the compounds of Formula (I), and to methods of preparing the compounds of Formula (I).本發明係有關式(I)化合物：其中X1、X2、X3、X4、X5、X6、X7、X8、R1、R2、R3係如下文定義。化合物具有凋亡信號調節劑激酶(“ASK1”)抑制活性，且因此可用於治療由ASK1介導之病狀，包括自體免疫病症、發炎性疾病、心血管疾病及神經退化疾病。本發明亦有關醫藥組成物，其包含一或多種式(I)化合物，及製備式(I)化合物之方法。